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Mefloquine Hydrochloride Tablets, USP are an antimalarial agent available as 250-mg tablets of Mefloquine hydrochloride (equivalent to 228.0 mg of the free base) for oral administration.
Mefloquine hydrochloride is a 4-quinolinemethanol derivative with the specific chemical name of (R*, S*)-(±)-±-2-piperidinyl-2, 8-bis(trifluoromethyl)-4-quinolinemethanol hydrochloride. It is a 2-aryl substituted chemical structural analog of quinine. The drug is a white to almost white crystalline compound, slightly soluble in water.
Mefloquine hydrochloride has a calculated molecular weight of 414.78 and the following structural formula:
Each tablet, for oral administration, contains 250 mg Mefloquine hydrochloride and the following inactive ingredients: colloidal silicon dioxide, corn starch, crospovidone, lactose monohydrate, lactose spray dried, magnesium stearate, microcrystalline cellulose, polysorbate 80, polyvinylpyrrolidone and talc.